Causes The most common causes of gastritis are: Certain medications, such as aspirin, ibuprofen, or naproxen, when taken over a longer period of time ; Drinking too much alcohol; Infection of the stomach with a bacteria called Helicobacter pylori ; Less common causes are: Autoimmune disorders (such as pernicious anemia ); Backflow of bile into the stomach (bile reflux); Cocaine abuse; Eating or drinking caustic or corrosive substances (such as poisons); Extreme stress; Viral infection, such as cytomegalovirus and herpes simplex virus, especially in people with a weak immune system; Trauma or a severe, sudden illness such as major
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